Viral Evolution during Structured Treatment Interruptions in Chronically Human Immunodeficiency Virus-Infected Individuals
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (23) , 12344-12348
- https://doi.org/10.1128/jvi.76.23.12344-12348.2002
Abstract
We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.Keywords
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