Influence of different doses of interferon-α-2b on the blood plasma levels of 5-fluorouracil

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Abstract
Summary The blood plasma levels of 5-fluorouracil (5FU) after i.v. administration have been determined without and under the influence of 1, 5 or 9 million units (MU) preadministered interferon (IFN) in patients with gastrointestinal carcinoma. The co-administration of 9 MU IFN causes a doubled increase of the 5FU serum concentrations combined with a statistically significant change of the pharmacokinetics of 5FU for co AUC, Vd and Cltot (Po and AUC were elevated significantly (P0.05). A linear correlation between the IFN dose and the pharmacokinetic parameters co (R=0.958), AUC0–120 (R=0.948), Vd (R=0.941) and Cltot (R=0.963) of 5FU could be found (P1/2el. The results indicate that the pharmacokinetics of 5FU might be influenced by the preadministered IFN dose.