Determination of Copper in Plasma and Serum by Use of a Microsampling Cup in Atomic Absorption Spectrometry
- 1 September 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 20 (9) , 1199-1203
- https://doi.org/10.1093/clinchem/20.9.1199
Abstract
A microsampling cup procedure is described for rapid, precise determination of copper in plasma. Conventional Delves-cup atomic absorption spectrometry does not yield usable copper signals with blood plasma samples. Analytical sensitivity was improved 11-fold by use of cups fitted with an axial hole, a triangular cup-holding loop, and a smaller-bore absorption tube. The modified procedure yields relative standard deviations of 4-6% at the level of 95 µg of copper per deciliter. Analysis of 100 samples of blood plasma by both the microsampling cup procedure and a solvent-extraction atomic absorption procedure showed no significant difference between the two sets of data (P <.02).Keywords
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