Absence of mutations in the coding region of the α-synuclein gene in pathologically proven Parkinson's disease

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Abstract
A missense mutation of the α-synuclein gene has been associated with parkinsonism in a large Italian kindred. Recently, α-synuclein was also identified in Lewy bodies. Using reverse transcribed-polymerase chain reaction (RT-PCR) technique, we sequenced the entire coding region of theα-synuclein gene using brain tissue from 24 pathologically proven Parkinson9s disease cases. No mutations were found in any of the patients, suggesting that a mutation at the coding region of the α-synuclein gene is unlikely to be responsible for nigrostriatal degeneration in typical sporadic Parkinson9s disease.

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