Impairment of avoidance responding by lesions in cingulate cortex in rats depends on food drive.

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Abstract
Sham-operated control and cingulate-lesioned rats were conditioned in a double-grill box under high and low levels of hunger. The high irrelevant drive level was associated with significantly more shocked spontaneous responses and better conditioned-avoidance-response (CAR) performance than was observed in the satiated Ss. Lesioned Ss under high drive showed no performance deficit, but Ss under low drive showed significant loss in CAR performance. It is suggested that lesions affect performance by enhancing the tendency of rats to freeze in response to the CS and the high hunger drive counteracts the freezing response by inducing heightened general activity which protects Ss from lesion-induced behavioral loss. (15 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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