Opiate Peptide Modulation of Amino Acid Responses Suggests Novel Form of Neuronal Communication
- 31 March 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4336) , 1451-1453
- https://doi.org/10.1126/science.204016
Abstract
Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.This publication has 36 references indexed in Scilit:
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