The effect of various drugs on aorto-coronary vein bypass flow

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Abstract
The capacity of the coronary bed, distal to an aorto-coronary vein bypass, was studied in 20 patients. The flow capacity was tested with the aid of various drugs; papaverine hydrochloride, isoproterenol, dipyrid-amole and isosorbide dinitrate. The evaluation of the capacity was made by measuring the flow through the vein bypass peroperatively and during the first postoperative days. The bypass flow is directly related to the peripheral resistance if the blood pressure, viscosity and other factors according to the law of Poiseuille are constant. The effect of the drugs tested in the present study might therefore influence the peripheral resistance or the blood viscosity. Peroperative injection of papaverine into the vein graft gave a pronounced increase of the vein bypass flow. In the postoperative tests isoproterenol showed a mean increase of the graft flow of 70%, probably due to the augmented oxygen demand caused by increased contractility and tachycardia. Dipyridamole gave a significant vasodilation with a mean flow increase of 49% without modifications of the blood pressure or the heart rate. Isosorbide dinitrate failed to influence the aorto-coronary vein bypass flow.

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