CHARACTERIZATION OF HIGH AFFINITY CHOLINE UPTAKE BY TORPEDO CALIFORNICA T‐SACS
- 1 December 1979
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 33 (6) , 1189-1194
- https://doi.org/10.1111/j.1471-4159.1979.tb05263.x
Abstract
Abstract— The high affinity choline uptake system present in T‐sacs prepared from Torpedo californica electric organ was shown to be insensitive to external Ca2+ and to be absolutely dependent on external NaCl, with optimal uptake at approx 200 mM‐NaCl. Both Na+ and Cl− separately stimulate uptake. Uptake also exhibited an optimum at approx 10mM‐external K+. Uptake was completely inhibited at 4°C. Approximately 50% of newly accumulated [3H]choline was released by depolarization of T‐sacs regardless of the time or method of depolarization.This publication has 33 references indexed in Scilit:
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