Mutation of a Single Lytic Transglycosylase Causes Aberrant Septation and Inhibits Cell Separation of Neisseria gonorrhoeae

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Abstract
The function of lytic peptidoglycan transglycosylases is poorly understood. Single lytic transglycosylase mutants of Escherichia coli have no growth phenotype. By contrast, mutation of Neisseria gonorrhoeae ltgC inhibited cell separation without affecting peptidoglycan monomer production. Thus, LtgC has a dedicated function in gonococcal cell division.