Biological variability of regional deposition of aerosol particles in the human respiratory tract

Abstract
Regional deposition of inhaled particles was studied experimentally for 9 health subjects breathing the same aerosol under the same breathing conditions to evaluate intersubject variability of regional deposition. Intersubject variability of extrathoracic, tracheobronchial and alveolar deposition was found. The highest was observed for particle deposition in extrathoracic airways. This biological variability of regional deposition has to be taken into account for considerations of health-related aspects of aerosol inhalation.

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