A simple method for the configurational analysis of a deoxynucleoside 5′-[16O,18O,S]phosphorothioate

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Abstract
Methylation of 2′-deoxyadenosine 5′-phosphorothioate gives two diastereoisomeric triesters whose configurations can be assigned by 31P n.m.r. spectroscopy by methylation of an asymmetric mixture of the diastereoisomers of 2′-deoxyadenosine 5′-O-methylphosphorothioate after configurational assignment; this can be used as a simple method for stereochemical analysis of 2′-deoxyadenosine 5′-[16O,18O]phosphorothioate.