Effect of the leucomycin-like macrolide antibiotic turimycin on ribosomal peptidyltransferase from Escherichia coli.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (12) , 1314-1319
- https://doi.org/10.7164/antibiotics.29.1314
Abstract
The relationship between the effect of different turimycin components on ribosomal peptidyltransferase of E. coli, antimicrobial [antibacterial] activity and chemical structure were studied. Inhibition of peptidyltransferase and antimicrobial activity increased with the length of the aliphatic side chain in 4"-position of mycarose and decreased with acylation in 3-position of the lactone ring. Inhibition of peptidyltransferase is paralleled by inhibition of acceptor substrate binding.This publication has 1 reference indexed in Scilit:
- Inhibitors of Ribosome FunctionsAnnual Review of Microbiology, 1971