STEROID BIOSYNTHESIS IN VITRO BY A VIRILIZING SUPRARENAL TUMOUR

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Abstract
A case of virilizing adrenal adenoma is described. The tumor was incubated with progesterone-4-C14. In the extract the following steroids were identified chromatographically, in order of decreasing quantity and radioactivity: 17[alpha]-hydroxyprogesterone, androst-4-ene-3,17-dione, corticosterone (ll[beta],21-dihydroxy-pregn-4-ene-3,20-dione), cortisol (11[beta],17,21-trihydroxy-pregn-4-ene-3,20-dione) and 11-deoxycortisol. This indicates either an increase in 17[beta]-hydroxylation and side chain split, or a partial blockage of 21-hydroxylation, or a combination of both in the tumor tissue. The absence of the 3[beta]- hydroxy-dehydrogenase demonstrated histochemically in the tumor and the examination of the urinary 17-ketosteroids before and after removal of the neoplasm, suggested the same abnormal biosynthetic pattern in vivo with regard to the level of the endogenous [LAMBDA]5-precursors.

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