Activities of a Soluble Extract from Lymphoid Cells of MRL Mice

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Abstract
Soluble extract (sEx) was prepared from lymphoid cells of MRL/Mp-lpr/lpr (MRL/l) mice with early lupus nephritis and also of MRL/Mp- +/+ (MRL/n) mice. sEx from lymph node and spleen T cells of MRL/l mice had an activity for B cells to differentiate into immunoglobulin-producing cells but that of MRL/n mice did not show such an activity. sEx of MRL/l mice also enhanced the in vitro response of B cells to a suboptimal dose of lipopolysaccharide. Implication of these phenomena in the development of lupus nephritis is discussed.