The telosome/shelterin complex and its functions
Open Access
- 1 January 2008
- journal article
- review article
- Published by Springer Nature in Genome Biology
- Vol. 9 (9) , 232
- https://doi.org/10.1186/gb-2008-9-9-232
Abstract
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.Keywords
This publication has 94 references indexed in Scilit:
- DNA damage response at functional and dysfunctional telomeresGenes & Development, 2008
- Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisThe EMBO Journal, 2007
- Protection of telomeres by a conserved Stn1–Ten1 complexProceedings of the National Academy of Sciences, 2007
- Telomere Maintenance through Spatial Control of Telomeric ProteinsMolecular and Cellular Biology, 2007
- Tetrahymena POT1a Regulates Telomere Length and Prevents Activation of a Cell CycleCheckpointMolecular and Cellular Biology, 2007
- Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein StabilityMolecular and Cellular Biology, 2006
- POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationThe EMBO Journal, 2006
- Vertebrate POT1 Restricts G-Overhang Length and Prevents Activation of a Telomeric DNA Damage Checkpoint but Is Dispensable for Overhang ProtectionMolecular and Cellular Biology, 2006
- A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyProceedings of the National Academy of Sciences, 2006
- ORC binding to TRF2 stimulates OriP replicationEMBO Reports, 2006