Immune Responses to Retinal Self-Antigens in CD25+CD4+Regulatory T-Cell–Depleted Mice
- 1 June 2004
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 45 (6) , 1879-1886
- https://doi.org/10.1167/iovs.02-1030
Abstract
Purpose. Prior work has shown that autoimmune uveoretinitis develops spontaneously in CD25+CD4+ regulatory T-cell–depleted mice (Tr-depleted mice). In this study, the generation of autoantibodies and autoreactive T-cells specific to retinal antigens was examined in Tr-depleted mice with uveoretinitis, and the pathogenic and immunogenic abilities of the autoreactive T cells were evaluated.Keywords
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