The Effects of Intragastric Ethanol Administration upon Canine Exocrine Pancreatic Secretion

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Abstract
The effects of intragastric administration of ethanol on exocrine pancreatic secretion were assessed in 11 mongrel dogs provided with gastric and pancreatic fistulae (Thomas cannula). The gastric fistula was left open throughout the experiments to prevent gastric content from entering the duodenum. Ethanol (12% in saline) decreased the protein concentration and the output of basal pancreatic secretion. Ethanol (40% in saline) showed no effect upon pancreatic secretion stimulated by a continuous intravenous injection of GIH secretin (1.0 U/kg/h) but produced a significant increase in protein concentration and output when pancreatic secretion was stimulated by a continuous intravenous injection of Boots secretin (4.0 U/kg/h). Intragastric infusion of 80-percent (v/v) ethanol under intravenous injection of GIH secretin (1.0 U/kg/h) produced an inhibition of the flow rate and alkaline secretion and a significant increase in protein concentration and output. The latter response was suppressed by previous antrectomy.

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