Presence of Identical Antigenic Determinants in the Fd Fragments of γ1- and γ2-Guinea Pig Immunoglobulins

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Abstract
Summary: Rabbit antisera prepared against guinea pig γ2-globulin digested by pepsin react with isolated H and L chains. They contain antibodies against part of the H chain, the Fd fragment, and not against the Fc fragment. These antisera, directed against L chains and Fd fragments from γ2-globulins, do not detect any differences between γ1- and γ2- guinea pig immunoglobulins, when double diffusion in gel techniques are used. These results show that not only L chains but also Fd fragments of these different classes of immunoglobulins have common antigenic determinants.

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