Synthesis of the tetrahydroisoquinoline unit in the AB ring system of the novel antitumor-antibiotic tetrazomine

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Abstract
The elaboration of a polysubstituted 7-amino tetrahydroisoquinoline derivative which embodies the central AB ring system of the novel antitumor-antibiotic tetrazomine, employing a highly selective ortho nitration and Jackson tosylamido acetal cyclisation as crucial steps, is reported.

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