Immunocytochemical Localization of Mouse Alpha 2-Macroglobulinlike Antigenic Determinants on Schistosoma mansoni Adults

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Abstract
Antiserum prepared in rhesus monkeys against purified mouse .alpha.2-macroglobulin (.alpha.2M) was labeled with peroxidase and incubated with living and formalin-fixed S. mansoni adults (perfused from mice or rhesus monkeys) to test for the presence of mouse .alpha.2M antigenic determinants on their surfaces. Following standard cytochemical processing with the appropriate controls, adult worms of murine and primate origin had mouse .alpha.2M-like determinants on their surfaces. Earlier observations by other methods on the presence, approximate distribution, and quantitative difference of .alpha.2M antigenic determinants on adult worms of mouse or rhesus origin were confirmed.

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