STUDIES WITH RADIOACTIVE DI-AZO DYES. 1. THE LOCALIZATION OF RADIOACTIVE DI-BROM TRYPAN BLUE IN INFLAMMATORY LESIONS

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Abstract
The authors review previous studies of the accumulation of trypan blue and related dyes in inflammatory lesions. They hypothecate that a radioactive dye of this group might become a useful clinical adjunct if it could be rendered radioactive, injected into subjects with inflammatory lesions and the accumulation of the radioactive dye detected with suitable physical equipment such as a Geiger counter. The accumulation of the dye in the abscess would then by its radioactive emanations indicate the presence of the abscess. To investigate this matter the authors have rendered trypan blue radioactive by the incorporation of 2 atoms of radioactive bromine (Br82) into the molecule, using a controlled synthetic method. Abscesses in rabbits of staphylococcic origin were then studied, the radioactive dye being injected intraven. The animals were "scanned" with a Geiger counter screened with Pb so as to detect the distribution of the radioactive dye. Using this technique they found leg abscesses detectable in 9 animals with no failures. Abdominal subcut. lesions were detectable in 77% of instances (16 animals). All control animals showed normal distribution of the dye with no "false accumulations." This or some related radioactive colloid may become useful in the clinical diagnosis and exact localization of inflammatory lesions in the body.

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