Lactic Acid Accumulation as a Cause of Hypoxia-Induced Malformations in the Chick Embryo
- 27 October 1961
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 134 (3487) , 1359-1360
- https://doi.org/10.1126/science.134.3487.1359
Abstract
Most hypoxia-induced malformations are caused by a syndrome involving tremendous edema followed by formation of clear blisters and hematomas. These, in turn, mechanically interfere with development. Studies of blood p H and lactic acid indicate that lactate accumulation initiates this syndrome. The effects of lactic acid injections parallel those of subjection to hypoxia, confirming this conclusion.Keywords
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