THE SYNTHESIS OF 5-METHYLURIDINE 5′-PHOSPHATE IN RAT EMBRYO EXTRACTS
- 1 May 1960
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 46 (5) , 632-636
- https://doi.org/10.1073/pnas.46.5.632
Abstract
A method for estimating the methylation of uridine-monophosphate (UMP) and d-UMP in tissue extracts is presented. By this procedure it has been demonstrated that UMP is converted to 5-methyl UMP in extracts of rat embryos. This reaction requires the presence of tetrahydro-folic acid and formaldehyde and appears to be a accompanied by intermediates or side products, as revealed by radioautography.Keywords
This publication has 15 references indexed in Scilit:
- Alternative Pathways of Thymine and Uracil Metabolism in the Liver and Hepatoma23JNCI Journal of the National Cancer Institute, 1960
- The enzymic conversion of glucosamine to galactosamineBiochimica et Biophysica Acta, 1959
- VIRUS-INDUCED ACQUISITION OF METABOLIC FUNCTION .3. FORMATION AND SOME PROPERTIES OF THYMIDYLATE SYNTHETASE OF BACTERIOPHAGE-INFECTED ESCHERICHIA-COLI1959
- Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymusArchives of Biochemistry and Biophysics, 1958
- Interaction of Formaldehyde and Tetrahydrofolic Acid and Its Relation to the Enzymic Synthesis of SerineNature, 1958
- 5′-Deoxycytidylic acid deaminase enzymic production of 5′-deoxyuridylic acidBiochimica et Biophysica Acta, 1958
- The interconversion of serine and glycine: preparation and properties of catalytic derivatives of pteroylglutamic acidBiochemical Journal, 1957
- METABOLISM OF THYMINE (METHYL-C14 OR −2-C14) BY RAT LIVER IN VITROJournal of Biological Chemistry, 1956
- NUCLEOTIDE METABOLISM .2. CHROMATOGRAPHIC SEPARATION OF ACID-SOLUBLE NUCLEOTIDES1954
- THE ENZYMATIC SYNTHESIS OF NUCLEOSIDES .2. THYMIDINE AND RELATED PYRIMIDINE NUCLEOSIDES1954