Desolvation Energy: A Major Determinant of Absorption, But Not Clearance, of Peptides in Rats
- 1 January 1991
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 08 (12) , 1477-1481
- https://doi.org/10.1023/a:1015882030289
Abstract
The oral delivery of peptidic drugs is problematic because of their degradation in the gastrointestinal tract and low absorption through the intestinal mucosa. Earlier in vitrostudies with two...Keywords
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