Correlation between three-dimensional structure and chemical reactivity of transfer RNA
- 1 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 1 (7) , 927-932
- https://doi.org/10.1093/nar/1.7.927
Abstract
The bases of yeast tRNA Phe which react with carbodiimide and methoxyamine have been determined and this information has been combined with chemical modification studies of other workers to produce a composite picture of base accessibility in this tRNA. The results are compared with the three-dimensional structure which we have recently determined. The bases which react chemically lie in exposed positions in the three-dimensional model and those which do not are either in the double helical stem regions or else are involved in maintaining the tertiary structure through pairing or stacking interactions.Keywords
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