Topically Applied Steroids in Corneal Disease
- 1 October 1974
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 92 (4) , 329-330
- https://doi.org/10.1001/archopht.1974.01010010339016
Abstract
Topical application of a commercially available aqueous suspension of dexamethasone alcohol, 0.1%, produced measurable quantities of the steroid in both the cornea and in the aqueous humor under all three experimental ocular conditions studied. Drug bioavailability was greatest after removal of the corneal epithelium, but the alcohol derivative of dexamethasone also penetrates through the intact corneal epithelium. Comparison of our present findings with previous experimental data from this laboratory confirms the superiority of an aqueous vehicle over petrolatum ointment for delivering dexamethasone to the eye.Keywords
This publication has 1 reference indexed in Scilit:
- Factors Influencing Solvolysis of Corticosteroid-21-Phosphate EstersJournal of Pharmaceutical Sciences, 1970