α1‐Adrenergic stimulation causes Mg2+ release from perfused rat liver
- 27 March 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 246 (1-2) , 127-130
- https://doi.org/10.1016/0014-5793(89)80267-4
Abstract
The possibility that Mg2+ mobilization is stimulated in perfused liver by α1-adrenergic agonists was studied by measuring Mg2+ release in response to 0.5 and 20μM phenylephrine. During preperfusion exogenous Mg2+ was added to the medium to give 1.2 mM. 5 min before starting the addition of phenylephrine the infusion of exogenous Mg2+ was stopped. Mg2+ in the perfusate leaving the liver was measured by atomic absorption spectroscopy. Analysis of the Mg2+ decay curves with two exponential models indicated that phenylephrine caused dose-dependent Mg2+ release from perfused rat liversKeywords
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