Estrogen biosynthesis: metabolism of [16,16,19-2H3][19-3H] 19-oxoandrost-4-ene-3,17-dione by a placental microsomal preparation

Abstract
Incubation of the title compound with a microsomal placental preparation gave in addition to the expected metabolites several new products, three of which were identified as [16,16-2H2] 19-norandrost-4-ene-3,17-dione, [16,16-2H2] 19-norandrosta-4,6-diene-3,17-dione, and [16,16,19-2H3][19-3H] 19-hydroxyandrosta-4,6-diene-3,17-dione.

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