The Utilization of Secondary Phosphine Oxide Synthons for the Preparation of Novel Tertiary Phosphine Oxide Modified DNA

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Abstract
Novel tertiary phosphine oxides are described which act as masked secondary phosphine oxides. The protection of the reactive P-H bond allows generation of a carbanion alpha to phosphorus and subsequent alkylation with an oxetane. The free P-H can then be liberated with anhydrous acid. This functionality can then be further alkylated to generate novel tertiary phosphine oxide backbone modified DNA.

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