A small molecule CFTR inhibitor produces cystic fibrosis‐like submucosal gland fluid secretions in normal airways
Open Access
- 4 March 2004
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 18 (7) , 875-877
- https://doi.org/10.1096/fj.03-1248fje
Abstract
Airway submucosal glands have been proposed as a primary site for initiating and sustaining airway disease in cystic fibrosis (CF). However, it has been difficult to define the role of CFTR in gland ...Keywords
Funding Information
- National Institutes of Health (HL73854, EB00415, EY13574, DK35124, DK43840)
This publication has 32 references indexed in Scilit:
- Disruptive effects of Anion Secretion Inhibitors on Airway Mucus Morphology in Isolated Perfused Pig LungThe Journal of Physiology, 2003
- Absent Secretion to Vasoactive Intestinal Peptide in Cystic Fibrosis Airway GlandsPublished by Elsevier ,2002
- Early airway infection, inflammation, and lung function in cystic fibrosisArchives of Disease in Childhood, 2002
- Mucus Secretion from Single Submucosal Glands of PigPublished by Elsevier ,2002
- Chloride Concentration in Endosomes Measured Using a Ratioable Fluorescent Cl− IndicatorJournal of Biological Chemistry, 2002
- Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pHJournal of Clinical Investigation, 2001
- Bicarbonate and Chloride Secretion in Calu-3 Human Airway Epithelial CellsThe Journal of general physiology, 1999
- The genesis of cystic fibrosis lung diseaseJournal of Clinical Investigation, 1999
- Submucosal glands are the predominant site of CFTR expression in the human bronchusNature Genetics, 1992
- Cystic fibrosis of the pancreas: structural changes in peripheral airwaysThorax, 1968