Necrosis and Regeneration of the Tibialis Anterior Muscle in Rabbit
- 1 October 1969
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 21 (4) , 373-380
- https://doi.org/10.1001/archneur.1969.00480160045005
Abstract
LIGATION of the anterior tibial artery in rabbits results in ischemic necrosis of the distal two thirds of the anterior tibial muscle. Regeneration of the muscle fibers is almost complete within 90 days. The process of morphological regeneration is described in detail in previous papers.1,2Biochemical studies during necrosis and regeneration of the muscle fibers are presented in this paper. Materials and Methods Fifteen adult rabbits of different species, origin, and sex, weighing between 2,350 gm (5 Ib 3 ounces) and 5,100 gm (11 Ib- 4 ounces) were used. The anterior tibial artery of the right hind limb was ligated according to the method of Clark et al.3The animals were allowed to survive 1, 4, 6, 8, 10, 25, 35, 45, and 90 days and then were killed. Both anterior tibial muscles were removed immediately after death and treated as previously described.2The muscles ofKeywords
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