Initial cholesterol esterif ication rate in hyperlipoproteinaemia: effects of triglyceride‐rich Iipoproteins

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Abstract
The initial cholesterol esterification rate (lecithin:cholesterol acyltransferase; LCAT) was determined in 94 hyperlipidemic subjects. LCAT activity was elevated in hypertriglyceridemia, whereas patients with hypercholesterolemia had normal activities. In hypertriglyceridemic subjects LCAT activity correlated with the concentrations of d [density] < 1.006 lipoproteins, plasma triglycerides, cholesterol and cholesterol esters and phospholipid levels. Addition of d < 1.006 lipoprotein to normal plasma resulted in a dose-dependent stimulation of enzyme activity with a sigmoidal response curve. When the d < 1.006 lipoproteins were removed from hypertriglyceridemic plasma by ultracentrifugation, the enzyme activity in the residual d > 1.006 fraction dropped, but still was higher than in normal plasma and correlated with the amount of d < 1.006 lipoproteins originally present. High LCAT activity in hypertriglyceridemia cannot be explained solely by the presence of an increased d < 1.006 lipoprotein concentration. An increase of enzyme concentration or changes in concentration or composition of other lipoproteins (high density lipoproteins) may contribute to the high LCAT activity in hypertriglyceridemia.

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