Effects of Canine Fetal Testes and Testicular Tumors on Müllerian Ducts

Publisher Website
Google Scholar
Abstract
The effects of canine fetal and adult testes and testicular tumors on reproductive tracts from 14.5 day old rat fetuses cultured in vitro were investigated. Muellerian inhibiting activity (MIA) was found in fetal canine testes, confirming the lack of species specificity of the Muellerian inhibiting substance. Adult testes and testicular tumors were unable to produce regression of Muellerian ducts. The disappearance of MIA in adult testes in vitro contrasted with active secretion of testosterone. The absence of MIA in testicular tumors, including sertolinomas is discussed.