Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculoneuropathy
- 1 January 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (1) , 147
- https://doi.org/10.1212/wnl.37.1.147
Abstract
We elected to use cyclosporin A (CsA) in a woman debilitated by refractory chronic inflammatory demyelinating polyradiculoneuropathy. Although strength improved coincident with CsA therapy, after 21 months she developed congestive heart failure and had a precipitous loss of renal function with chronic renal failure requiring hemodialysis. While most CsA-induced nephrotoxicity is dose related and reversible, the kidney biopsy in our patient showed chronic nephropathy, a complication previously unreported in the native kidney of a nontransplant patient. A slow rise in blood pressure preceded serum creatinine changes and was an early indicator of impending irreversible nephrotoxicity.This publication has 2 references indexed in Scilit:
- Cyclosporine: A New Immunosuppressive Agent for Organ TransplantationAnnals of Internal Medicine, 1984
- Cyclosporine-Associated Chronic NephropathyNew England Journal of Medicine, 1984