ESR of cation radicals of phenothiazine derivatives

Publisher Website
Google Scholar
Abstract
Phenothiazines are of interest as model heterocyclic compounds and also as pharmacological agents with a wide spectrum of biological activities. Cation radicals derived from six phenothiazine derivatives including phenothiazine, 2‐chlorophenothiazine, promazine, chlorpromazine, promethazine and trimeprazine have been studied in aqueous solution by electron spin resonance. Their high‐resolution electron spin resonance spectra have been fully analysed, and hyperfine splitting parameters have been compared with those obtained in other solvent systems where available. Previously undetected hyperfine splittings of about 0.2–0.4 G from γ‐protons on the alkyl chain were observed for promazine, promethazine and, possibly, chlorpromazine.

This publication has 21 references indexed in Scilit: