Perspective: New genetic tools for studying retinal development and disease
- 1 September 2005
- journal article
- review article
- Published by Maximum Academic Press in Visual Neuroscience
- Vol. 22 (5) , 553-560
- https://doi.org/10.1017/s0952523805225026
Abstract
The use of knock-out and transgenic mice has been instrumental for advancing our understanding of retinal development and disease. In this perspective, we review existing genetic approaches to studying retinal development and present a series of new genetic tools that complement the use of standard knock-out and transgenic mice. Particular emphasis is placed on elucidating cell-autonomous and non-cell-autonomous roles of genes important for retinal development and diseasein vivo. In addition, a series of gene-swapping vectors can be used to elucidate the function of proteins that regulate key processes in retinal development and a wide variety of retinopathies.Keywords
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