THE EFFECT OF ESERINE AND NEOSTIGMINE ON THE BLOOD PRESSURE OF CONSCIOUS RATS

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Abstract
Small amounts of eserine salicylate (10 to 20 μg.) regularly caused a rise of blood pressure in non-anaesthetized rats. Neostigmine methylsulphate in doses from 1 to 10 μg./animal usually caused a fall of blood pressure, or no change was observed; only in a few experiments was a rise of blood pressure noted. The pressor effect of eserine was abolished by atropine and reduced or abolished by yohimbine and phentolamine. Adrenalectomy did not change the response to eserine. The present experiments do not contradict earlier statements that the pressor effect of eserine was due to the discharge of impulses from a centre or centres in the central nervous system.