Enzymatic Méthylation of Alkane Thiols
- 1 July 1979
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 24 (5) , 307-312
- https://doi.org/10.1159/000458680
Abstract
A membrane-bound enzymatic activity has been found in rabbit liver microsomes, which catalyses the transmethylation from S-adenosylmethionine to a series of C(1)—C(3) alkane thiols. Methane and ethane thiols are known to be endogenous toxins, which may play an important role in the pathogenesis of hepatic coma, and méthylation could provide an important pathway for the metabolic ‘detoxification’ of this class of compounds through neutralisation of the highly reactive sulph-hydryl group.Keywords
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