Phenol oxidation and biosynthesis. Part XI. The structure of stebisimine and the biosynthesis of epistephanine

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Abstract
A new bisbenzylisoquinoline alkaloid, stebisimine, has been isolated from Stephania japonica Miers and shown by physical methods and chemical degradation to be N-nor-1,2-dehydro-epistephanine. Tracer experiments have shown that half of the epistephanine molecule is derived exclusively from (–)-N-methylcoclaurine but not from its enantiomer. This confirms the absolute configuration of the alkaloid and shows that racemisation of the (+)-enantiomer is unimportant in this plant.

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