A new, sensitive, non-destructive detector for liquid chromatography, designated the Spray Impact Detector, is introduced in this paper and its advantages and disadvantages enumerated. Violent rupturing of a stream of the mobile phase at a target electrode creates a baseline current (or voltage) that changes upon elution of an organic or inorganic compound. Fatty acids, bile acid salts, β-diketones and their metal chelates, alkylsulfonates, detergents and other surface active agents, amino acids, amines as well as inorganic salts, acids and bases are among those compound types detectable in the 10−9 to 10−11 g/sec range. A linear dynamic range of three to four orders of magnitude is typical. Reverse-phase chromatography using water as mobile phase has been studied in greatest detail; however, methyl ethyl ketone, acetonitrile, and acetonitrile/water mixtures have also proved useful as mobile phases.