An Escherichia Coli Antigen Cross-Reactive with the Capsular Polysaccharide of Haemophilus Influenzae Type b: Occurrence Among Known Serotypes, and Immunochemical and Biologic Properties of E. Coli Antisera Toward H. Influenzae Type b
Open Access
- 1 June 1972
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 108 (6) , 1551-1562
- https://doi.org/10.4049/jimmunol.108.6.1551
Abstract
An Escherichia coli antigen was shown to be cross-reactive with the capsular polysaccharide of Hemophilus influenzae type b. The cross-reactive antigen was identified as a thermostable, acidic, capsular polysaccharide consistent with its designation as E. coli “K” antigen (type A). Antibodies raised by intravenous injection of formaldehyde-treated E. coli possessing the cross-reactive antigen precipitated with the H. influenzae type b capsular polysaccharide and had “protective” activity against H. influenzae type b in biologic assays. The cross-reactive antigen was identified in E. coli with various O and H serotypes and did not appear to be associated with pathogenicity.Keywords
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