On the relationship between incorporation of32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells

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Abstract
The lipophilic beta-adrenoceptor blocking drugs exaprolol and propranolol significantly decreased the incorporation of32P into phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol of isolated rat mast cells. In contrast, the hydrophilic drugs metipranolol, practolol and atenolol increased the incorporation of32P into phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol. The inhibition of32P incorporation by lipophilic drugs correlated with the high binding of these drugs to mast cells.