SCREENING OF AGENTS WHICH CONVERT TRANSFORMED MORPHOLOGY OF ROUS-SARCOMA VIRUS-INFECTED RAT-KIDNEY CELLS TO NORMAL MORPHOLOGY - IDENTIFICATION OF AN ACTIVE AGENT AS HERBIMYCIN AND ITS INHIBITION OF INTRACELLULAR SRC KINASE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 76  (8) , 672-675
Abstract
During the course of screening of agents active in converting the transformed morphology of Rous sarcoma virus-infected rat kidney cells to the normal morphology, an active substance produced by Streptomyces sp. MH237-CF8 has been identified as herbimycin. Herbimycin converted almost all cells into the normal morphology. The antibiotic was found to be an inhibitor of p60src-associated protein kinase in the cells.

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