PPARs in the Control of Uncoupling Proteins Gene Expression
Top Cited Papers
Open Access
- 26 November 2006
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2007, 1-12
- https://doi.org/10.1155/2007/74364
Abstract
Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in the control of energy conversion in mitochondria. Experimental and genetic evidence relate dysfunctions of UCPs with metabolic syndrome and obesity. The PPAR subtypes mediate to a large extent the transcriptional regulation of the UCP genes, with a distinct relevance depending on the UCP gene and the tissue in which it is expressed. UCP1 gene is under the dual control of PPAR and PPAR in relation to brown adipocyte differentiation and lipid oxidation, respectively. UCP3 gene is regulated by PPAR and PPAR in the muscle, heart, and adipose tissues. UCP2 gene is also under the control of PPARs even in tissues in which it is the predominantly expressed UCP (eg, the pancreas and liver). This review summarizes the current understanding of the role of PPARs in UCPs gene expression in normal conditions and also in the context of type-2 diabetes or obesity.Keywords
Funding Information
- Ministerio de Educación y Ciencia, Spain (SAF 2005-01722, FIS-PI052336)
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