Nickel-Catalyzed Tandem Coupling of α,β-Enones, Alkynes, and Alkynyltins for the Regio- and Stereoselective Synthesis of Conjugated Enynes

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Abstract
The nickel-catalyzed reaction of α,β-enones 2 with alkynes 1, alkynyltins 6, and Me3SiCl was carried out by the successive construction of two carbon−carbon bonds to give enol silyl ethers 5, which were then hydrolyzed to conjugated enynes 7, with high regio- and stereoselectivities (isomeric purities: 92−98%).

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