An Improved Synthesis of a Mixture of Diethyl (Z)- and (E)-3-Methylglutaconates from Ethyl Acetoacetate
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (12) , 1221-1222
- https://doi.org/10.1055/s-1993-35864
Abstract
A simple, efficient two-step synthesis of a mixture of diethyl (Z)- and (E)-3-methylglutaconates from isodehydroacetic acid in 83 % yield is described. On the basis of this synthesis an improved procedure for the preparation of a mixture of (Z)- and (E)-3-methylglutaconic acids from ethyl acetoacetate in 44 % overall yield was elaborated.Keywords
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