Proliferative Activity of the Cells of Acute Leukaemia in Relapse and in Steady State

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Abstract
The labelling index (L.L) of bone marrow and peripheral blast cells was determined with thymidine-H3 in expansion and steady state conditions of the leukemic blast population. A higher L.I. in the total population was observed in the expanding forms and these forms also presented a higher percentage of large and more actively proliferating blasts both in bone marrow and peripheral blood. In all cases the bone marrow L.L was higher than that in the peripheral blood. A higher percentage of large cells was observed in the bone marrow. The transformation of large blasts into small is considered as a possible regulator mechanism of the expansion of the blast population and responsible for the accumulation of blasts in a non-proliferating compartment.

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