The Effects of Hemorrhage and Sodium Depletion on Plasma Concentrations of Angiotensin II and [des-Asp1Angiotensin II in the Rat

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Abstract
Plasma concentrations of angiotensin II (PAII) and [des-Asp1]angiotensin II (Pdes-Asp1-AII) were measured before and after hemorrhage and acute and chronic depletion of sodium. Graded hemorrhage increased PAII from 30 ± 5 to 220 ± 41 and 989 (526–1290) pmol/liter and Pdes-Asp1-AII from 47 ± 11 to 216 ± 72 and 532 ± 178 pmol/liter. Furosemide increased PAII from 26 ± 4 to 178 ± 37 but did not change Pdes-Asp1-AII (31 ± 3 to 31 ± 4 pmol/liter). Deprivation of dietary sodium increased PAII from 25 ± 6 to 136 ± 22 pmol/liter and Pdes- Asp1-AII from 31 ± 4 to 71 ± 15 pmol/liter. The ratio of PAII to Pdes-Asp1-AII was increased by all three stimuli (P < 0.05 to P 1-AII II is unlikely to mediate the effects of hemorrhage and changes in sodium balance on aldosterone secretion in the rat.