Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers
- 1 March 1979
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 379 (2) , 143-147
- https://doi.org/10.1007/bf00586940
Abstract
Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0–2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.Keywords
This publication has 17 references indexed in Scilit:
- Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medullaPublished by Elsevier ,2003
- Morphine and met-enkephalin effects of sural aδ- afferent terminal excitabilityEuropean Journal of Pharmacology, 1978
- Opiate receptors in cultures of fetal mouse dorsal root ganglia (DRG) and spinal cord: predominance in DRG neuritesBrain Research, 1978
- Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in CultureScience, 1978
- Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniquesPain, 1977
- The effect of morphine on mammalian nerve fibresEuropean Journal of Pharmacology, 1977
- Opiate analgesics inhibit substance P release from rat trigeminal nucleusNature, 1977
- Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate catBrain Research, 1976
- Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root sectionBrain Research, 1976
- Changes in the dorsal root potential with diazepam and with the analgesics aspirin, nitrous oxide, morphine and meperidineNeuropharmacology, 1974