AMINO ACID FORMATION FROM GLUCOSE IN THE ISOLATED ADRENOCORTICAL AND THYROID TISSUE OF THE RABBIT

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Abstract
Quantitative paper-radiochromatography was used for measuring the amino acid formation from uniformly labelled 14C-glucose in slices from the isolated adrenal cortex and the thyroid. In both these organs glucose was utilized in the synthesis of the following amino acids: alanine, aspartic acid, glutamic acid, glutamine, arginine, proline, glycine and isoleucine/leucine. Distinct differences were noted in the rate of formation of the individual amino acids; the value for alanine being no less than 5 times higher in the thyroid than in the adrenocortical tissue. While TSH had no effect on the conversion of glucose in the thyroid, there was a tendency for a lower amino acid (glutamine) formation, when the adrenal cortex was incubated with ACTH.

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